No, this is not the movie popularized by Mother Lily.
Mano po is a gesture done by Filipinos when they greet older people. It’s one of the highest form of respect. You take one hand of the elder and let the back of his fingers touch your forehead.

(photo from joemaya123 at wordpress)
There are various meanings to why Filipinos do this:
This gesture has been part of the Filipino culture for centuries and generations. Mix this with your “po” and “opo,” and you’re on your way to becoming a Filipino.